July 22, 1630 - Madame de Brinvilliers
Her crimes unfolded within the enclosed world of French aristocratic inheritance, where patience and access were the only tools required. Over a period of years, she administered poison to members of her own family to consolidate their estates, conducting what amounted to a methodical campaign behind a façade of social respectability. Unconfirmed accounts circulated after her execution that she had refined her methods on hospital patients and animals, lending her case an outsized reputation that helped ignite the broader Affaire des Poisons and a crisis of confidence in Parisian society.
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