November 4, 1905 - Nannie Doss
Over nearly three decades, Doss killed steadily and without apparent detection, moving through marriages and family relationships while poisoning those closest to her. The span of victims — husbands, grandchildren, a sister, a mother — reflects a pattern that operated entirely within domestic life, which is partly what allowed it to continue as long as it did. Her case drew significant public attention not only for the scale of the killing but for the contrast between her demeanor and the gravity of what she had done.
From Wikipedia
Nannie Doss (born November 4, 1905 – June 2, 1965) was an American serial killer responsible for the deaths of 11 people between 1927 and 1954. Doss was also referred to as the Giggling Granny, the Lonely Hearts Killer, the Black Widow, and Lady Blue Beard.
Doss finally confessed to the murders in October 1954, after her fifth husband died in a small hospital in Tulsa, Oklahoma. In all, it was revealed that she had killed four husbands, two children, one of her sisters, her mother, two grandsons, and a mother-in-law.
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