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April 12, 1961 - Enedina Arellano Félix

One of the few women to lead a major Mexican drug trafficking organization, she rose through the Tijuana Cartel not through violence but through financial acumen — managing money laundering operations and maintaining the international supply relationships that kept the cartel viable even as its male leadership was systematically arrested or killed. Her longevity in the role reflects both operational skill and an ability to adapt as the organization contracted around her. "Enedina Arellano Félix de Toledo (born April 12, 1961) is a Mexican drug lord who, alongside her brothers, founded the Tijuana Cartel and played a role as a logistical accountant for the criminal organization... She first started working behind the scenes as a money launderer for the Tijuana Cartel but then ended up leading the cartel after the arrest of her brother Eduardo Arellano Félix in 2008." — Wikipedia

From Wikipedia

Enedina Arellano Félix de Toledo (born April 12, 1961) is a Mexican drug lord who, alongside her brothers, founded the Tijuana Cartel and played a role as a logistical accountant for the criminal organization.

Throughout most of the 1990s, the Tijuana Cartel was headed by her six brothers, while Enedina advised and helped them in money laundering and financial administration. But after the fall of a financial mastermind in the cartel in 2000, Enedina took up the position. She first started working behind the scenes as a money launderer for the Tijuana Cartel but then ended up leading the cartel after the arrest of her brother Eduardo Arellano Félix in 2008.

Since most of her brothers are either incarcerated or deceased, Enedina has managed the financial aspect of the organization, overseen alliances, and taken the lead of the Tijuana Cartel alongside Luis Fernando (before his capture in 2014). Her historical contacts with drug suppliers in Colombia managed to keep the organization afloat.

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