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May 5, 1912 - William Dale Archerd

His method was clinical and nearly invisible — insulin administered in lethal doses, producing deaths that initially resembled natural causes. The decade-long span of his confirmed killings, combined with suspected additional victims, reflects how long such a technique could evade detection before forensic medicine caught up. His conviction marked a legal and scientific threshold, establishing for the first time in the United States that insulin could be prosecuted as a murder weapon.

From Wikipedia

William Dale Archerd

William Dale Archerd (May 5, 1912 – October 29, 1977) was an American serial killer who killed at least three people with insulin injections between 1956 and 1966 in Northern California. He was the first to be convicted of using insulin as a murder weapon in the US, and he is suspected in three more cases.

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